Emodin reduces intestinal fibrosis in rats with TNBS-induced colitis
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چکیده
منابع مشابه
Astragaloside IV reduces intestinal fibrosis in rats with TNBS-induced colitis
To investigate the anti-fibrotic effects of Astragaloside IV in rats with experimental colitis, and to explore the possible mechanisms, Sprague-Dawley Rats with colitis were induced by 2,4,6-trinitrobenzene sulphonic acid (TNBS). Forty-eight rats were randomly divided into normal group, TNBS model group, SB203580 group and Astragaloside IV group. 150 mg/kg TNBS dissolved in 50% ethanol were gav...
متن کاملRecombinant expressed vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats
AIM To investigate the modulatory effect of recombinant-expressed vasoactive intestinal peptide (VIP) analogue (rVIPa) on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. METHODS Forty-eight rats were randomized into six groups: normal control group (Control), model control group (TNBS), ethanol treatment group (ETOH), and VIP treatment groups with different dosage (rVIPa1nmol, r...
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Morusin is a prenylated flavonoid isolated from the root bark of Morus alba. Many studies have shown the ability of flavonoids to act as anti-inflammatory agents. The aim of this study was to evaluate the effect of morusin on experimentally colitis induced by 2,4,6-trinitrobenzensulfonic acid in Wistar rats and to compare it with sulfasalazine, a drug conventionally used in the treatment of inf...
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Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease in humans constituting a major health concern today whose prevalence has been increasing over the world. Production of reactive oxygen species (ROS) and disturbed capacity of antioxidant defense in IBD subjects have been reported. Antioxidants may play a significant role in IBD treatment. This study aimed at evaluatin...
متن کاملLocal Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model
Lactate has long been considered as a metabolic by-product of cells. Recently, this view has been changed by the observation that lactate can act as a signaling molecule and regulates critical functions of the immune system. We previously identified lactate as the component responsible for the modulation of innate immune epithelial response of fermented milk supernatants in vitro. We have also ...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2012
ISSN: 2219-2859
DOI: 10.11569/wcjd.v20.i28.2703